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Horner Syndrome

About the Disease

Horner syndrome is a combination of signs and symptoms caused by the disruption of a nerve pathway from the brain to the face and eye on one side of the body. Typically, Horner syndrome results in a decreased pupil size, a drooping eyelid and decreased sweating on the affected side of your face. Horner syndrome is the result of another medical problem, such as a stroke, tumor or spinal cord injury. In some cases, no underlying cause can be found. There's no specific treatment for Horner syndrome, but treatment for the underlying cause may restore normal nerve function.Horner syndrome is also known as Horner-Bernard syndrome or oculosympathetic palsy.

Horner syndrome usually affects only one side of the face. Common signs and symptoms include:

  • A persistently small pupil (miosis)
  • A notable difference in pupil size between the two eyes (anisocoria)
  • Little or delayed opening (dilation) of the affected pupil in dim light
  • Drooping of the upper eyelid (ptosis)
  • Slight elevation of the lower lid, sometimes called upside-down ptosis
  • Little or no sweating (anhidrosis) either on the entire side of the face or an isolated patch of skin on the affected side

Signs and symptoms, particularly ptosis and anhidrosis, may be subtle and difficult to detect.

Children

Additional signs and symptoms in children with Horner syndrome may include:

  • Lighter iris color in the affected eye of a child under the age of 1
  • Lack of redness (flushing) on the affected side of the face that would normally appear from heat, physical exertion or emotional reactions

A number of factors, some more serious than others, can cause Horner syndrome. It is important to get a prompt and accurate diagnosis. Get emergency care if signs or symptoms associated with Horner syndrome appear suddenly, appear after a traumatic injury, or are accompanied by other signs or symptoms, such as:

  • Impaired vision
  • Dizziness
  • Muscle weakness or lack of muscle control
  • Severe, sudden headache or neck pain

Horner syndrome is caused by damage to a certain pathway in the sympathetic nervous system. The sympathetic nervous system regulates heart rate, pupil size, perspiration, blood pressure and other functions that enable you to respond quickly to changes in your environment. The nerve pathway affected in Horner syndrome is divided into three groups of nerve cells (neurons).

1. First-order neurons - This neuron pathway leads from the hypothalamus at the base of the brain, passes through the brainstem and extends into the upper portion of the spinal cord. Problems in this region that can disrupt nerve function related to Horner syndrome include:

  • Stroke
  • Tumor
  • Diseases that cause the loss of the protective sheath on neurons (myelin)
  • Neck trauma
  • Cyst or cavity in the spinal column (syringomyelia)

2. Second-order neurons - This neuron path extends from the spinal column, across the upper part of the chest and into the side of the neck. Causes related to nerve damage in this region may include:

  • Lung cancer
  • Tumor of the myelin sheath (schwannoma)
  • Damage to the main blood vessel leading from the heart (aorta)
  • Surgery in the chest cavity
  • Traumatic injury

3. Third-order neurons - This neuron path extends along the side of the neck and leads to the facial skin and muscles of the iris and eyelids. Nerve damage in this region may be associated with the following:

  • Damage to the carotid artery along the side of the neck
  • Damage to the jugular vein along the side of the neck
  • Tumor or infection near the base of the skull
  • Migraines
  • Cluster headaches, a disorder that results in cylical patterns of severe headaches

Children

The most common causes of Horner syndrome in children include:

  • Injury to the neck or shoulders during delivery
  • Defect of the aorta present at birth
  • Tumor of the hormonal and nervous systems (neuroblastoma)
  • Unknown causes

In some cases the cause of Horner syndrome cannot be identified. This is known as idiopathic Horner syndrome.

In most nonemergency situations, you will start by seeing a family doctor or an eye specialist (ophthalmologist). You may be referred to a doctor specializing in nervous system disorders (neurologist) or a specialist in both neurological disorders and disorders affecting the eye and visual pathways (neuro-ophthalmologist).

What you can do?

Before your appointment, make a list that includes the following:

  • Signs or symptoms — or any changes from normal — that may be causing concern
  • Past and recent illnesses or injuries
  • All medications — including over-the-counter drugs and dietary supplements — and the dosage you take of each medication
  • Any significant changes or stresses in your lifeIf possible, provide your doctor with relatively recent photographs — but photos taken before the onset of symptoms. These images may help your doctor assess the current condition of your affected eye.

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    Dr. Prashanth L K

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    Apollo Hospitals, Bannerghatta Road

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    Dr. Rakesh Jadav

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    Apollo Hospitals, Bannerghatta Road

    Dr. Vikram Kamath

    Dr. Vikram Kamath

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    Apollo Hospitals, Bannerghatta Road

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    Apollo Hospitals, Greams Lane, Chennai

    Dr. Sivarajan Thandeswaran

    Dr. Sivarajan Thandeswaran

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    Dr. Manmohan Gavvala

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    Dr. P N Shobhvathy

    Dr. P N Shobhvathy

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